Departement für Chemie, Biochemie und Pharmazie

Lehre & Forschung

Lebenslauf

  • 1967-1970  diploma (technician, chemistry), Swiss Serum & Vaccine Institute Bern, Switzerland
  • 1970-1973  diploma (chemical engineer), Institute of Technology Burgdorf, Switzerland
  • 1973-1977  diploma, Biochemistry major, Dept. Biochemistry Univ. Fribourg, Switzerland
  • 1978-1981  Ph.D., Biochemistry, Dept. Biochemistry Univ. Bern, Switzerland
  • January to April 1980  Dept. Biochemistry Medical School, Univ. Bristol, UK
  • 1981-1982  PostDoc, Lab. Theor. Biol., NCI, National Inst. Health Bethesda, Maryland, USA
  • 1982-1983  PostDoc, Lab. Biochem. Metabolism, NIADDK, National Inst. Health Bethesda, Maryland, USA
  • 1983-1988  Scientific collaborator, Inst. Hyg. med., Microbiology Univ. Bern, Switzerland
  • 1989  Venia Docendi (Cell Biology), University of Bern, Medical Faculty
  • 1988-1994  Scientific expert, ZLB Central Laboratories 
  • 1994-2000  Head of Virolgy, R&D, Blood Transfusion Center SRK 
  • 2000-  Head of Virolgy, R&D, CSL Behring AG 
  • 1988-2017  Group leader, Department of Chemistry & Biochemistry, University of Bern

Forschungsschwerpunkt

The research of the virology group of Prof. Kempf is focused on the study of parvovirus B19 and minute virus of mice. Our main efforts have been concentrated in the early events of parvovirus infection and inactivation studies.

Publikationen

Jump to: Journal Article | Book Section | Conference or Workshop Item

Journal Article

Leisi, Remo; Ruprecht, Nico; Kempf, Christoph; Ros, Carlos (2013). Parvovirus B19 uptake is a highly selective process controlled by VP1u, a novel determinant of viral tropism. Journal of virology, 87(24), pp. 13161-13167. American Society for Microbiology 10.1128/JVI.02548-13

Wolfisberg, Raphael; Ruprecht, Nico; Kempf, Christoph; Ros, Carlos (2013). Impaired genome encapsidation restricts the in vitro propagation of human parvovirus B19. Journal of virological methods, 193(1), pp. 215-225. Elsevier 10.1016/j.jviromet.2013.06.003

Cai, Kang; Gröner, Albrecht; Dichtelmüller, Herbert O.; Fabbrizzi, Fabrizio; Flechsig, Eckhard; Gajardo, Rodrigo; von Hoegen, Ilka; Jorquera, Juan I.; Kempf, Christoph; Kreil, Thomas R.; Lee, Douglas C.; Moscardini, Mila; Pölsler, Gerhard; Roth, Nathan J. (2013). Prion removal capacity of plasma protein manufacturing processes. Transfusion, 53(9), pp. 1894-1905. Wiley-Blackwell 10.1111/trf.12050

Quattrocchi, Silva; Ruprecht, Nico; Bönsch, Claudia; Bieli, Sven; Zürcher, Christoph; Boller, Klaus; Kempf, Christoph; Ros, Carlos (2012). Characterization of the early steps of human parvovirus B19 infection. Journal of virology, 86(17), pp. 9274-9284. Baltimore: American Society for Microbiology 10.1128/JVI.01004-12

Dichtelmüller, Herbert O.; Biesert, Lothar; Fabbrizzi, Fabrizio; Falbo, Anna; Flechsig, Eckhard; Gröner, Albrecht; von Hoegen, Ilka; Kempf, Christoph; Kreil, Thomas R.; Lee, Douglas C.; Pölsler, Gerhard; Roth, Nathan J. (2011). Contribution to safety of immunoglobulin and albumin from virus partitioning and inactivation by cold ethanol fractionation: a data collection from Plasma Protein Therapeutics Association member companies. Transfusion, 51(7), pp. 1412-1430. Malden, Mass.: Wiley-Blackwell 10.1111/j.1537-2995.2010.03003.x

Bönsch, Claudia; Zuercher, Christoph; Lieby, Patricia; Kempf, Christoph; Ros, Carlos (2010). The globoside receptor triggers structural changes in the B19V capsid that facilitate virus internalization. Journal of virology, 84(22), pp. 11737-11746. Baltimore: American Society for Microbiology 10.1128/JVI.01143-10

Bönsch, Claudia; Kempf, Christoph; Müller, Ivo; Manning, Laurens; Laman, Moses; Davis, Timothy M.E.; Ros, Carlos (2010). Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication. PLoS neglected tropical diseases, 4(4), e669. San Francisco, Calif.: Public Library of Science 10.1371/journal.pntd.0000669

Dichtelmüller, Herbert O.; Biesert, Lothar; Fabbrizzi, Fabrizzio; Gajardo, Rodriguez; Gröner, Albrecht; von Hoegen, Ilka; Jorquera, Juan I.; Kempf, Christoph; Kreil, Thomas R.; Pifat, Dominique; Osheroff, Wendy; Poelsler, Gerhard (2009). Robustness of solvent/detergent treatment of plasma derivatives: a data collection from Plasma Protein Therapeutics Association member companies. Transfusion, 49(9), pp. 1931-1943. Malden, Mass.: Wiley-Blackwell 10.1111/j.1537-2995.2009.02222.x

Boensch, Claudia; Kempf, Christoph; Ros, Carlos (2008). Interaction of parvovirus B19 with human erythrocytes alters virus structure and cell membrane integrity. Journal of virology, 82(23), pp. 11784-11791. Baltimore: American Society for Microbiology 10.1128/JVI.01399-08

Stucki, Martin; Boschetti, Nicola; Schäfer, Wolfram; Hostettler, Thomas; Käsermann, Fabian; Nowak, Thomas; Gröner, Albrecht; Kempf, Christoph (2008). Investigations of prion and virus safety of a new liquid IVIG product. Biologicals, 36(4), pp. 239-247. London: Elsevier 10.1016/j.biologicals.2008.01.004

Mani, Bernhard; Gerber, Marco; Lieby, Patricia; Boschetti, Nicola; Kempf, Christoph; Ros, Carlos (2007). Molecular mechanism underlying B19 virus inactivation and comparison to other parvoviruses. Transfusion, 47(10), pp. 1765-1774. Malden, Mass.: Wiley-Blackwell 10.1111/j.1537-2995.2007.01393.x

Kempf, Christoph; Stucki, Martin; Boschetti, Nicola (2007). Pathogen inactivation and removal procedures used in the production of intravenous immunoglobulins. Biologicals, 35(1), pp. 35-42. London: Elsevier 10.1016/j.biologicals.2006.01.002

Ros, Carlos; Baltzer, Claudia; Mani, Bernhard; Kempf, Christoph (2006). Parvovirus uncoating in vitro reveals a mechanism of DNA release without capsid disassembly and striking differences in encapsidated DNA stability. Virology, 345(1), pp. 137-147. New York, N.Y.: Academic Press 10.1016/j.virol.2005.09.030

Mani, Bernhard; Baltzer, Claudia; Valle, Noelia; Almendral, José; Kempf, Christoph; Ros, Carlos (2006). Low pH-dependent endosomal processing of the incoming parvovirus minute virus of mice virion leads to externalization of the VP1 N-terminal sequence (N-VP1), N-VP2 cleavage, and uncoating of the full-length genome. Journal of virology, 80(2), pp. 1015-1024. Baltimore: American Society for Microbiology 10.1128/JVI.80.2.1015-1024.2006

Bauman, P; Lawrence, LA; Biesert, L; Dichtelmüller, H; Fabbrizzi, F; Gajardo, R; Gröner, A; Jorquera, JI; Kempf, Christoph; Kreil, TR; von Hoegen, I; Pifat, DY; Petteway, SR Jr; Cai, K (2006). Critical factors influencing prion inactivation by sodium hydroxide. Vox sanguinis, 91(1), pp. 34-40. Oxford: Wiley-Blackwell 10.1111/j.1423-0410.2006.00790.x

Käsermann, Fabian; Kempf, Christoph (2006). Virus membrane proteins and proteinaceous pores. Future virology, 1(6), pp. 823-831. London: Future Medicine Ltd. 10.2217/17460794.1.6.823

Ros, Carlos; Gerber, Marco; Kempf, Christoph (2006). Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity. Journal of virology, 80(24), pp. 12017-12024. Baltimore: American Society for Microbiology 10.1128/JVI.01435-06

Book Section

Kempf, Christoph; Späth, Peter Julius (2013). Pathogen safety of Immunoglobulin Preparations. In: Clinical use of immunoglobulins (pp. 33-57). Bremen: UNI-med

Zuercher, Adrian W.; Amsler, Lorenz; Amstutz, Hanspeter; Andresen, Irmgard; Bolli, Reinhard; Hummel, Wolfram; Käsermann, Fabian; Kempf, Christoph; Lerch, Peter; Lörtscher, Marius; Schaub, Alexander; Spycher, Martin; Miescher, Sylvia M. (2011). C2 Plasma-derived immunoglobulins. In: Nijkamp, Frans P.; Parnham, Michael J. (eds.) Principles of Immunopharmacology, Part 3 (pp. 271-301). Heidelberg: Springer Verlag 10.1007/978-3-0346-0136-8_17

Borte, M; Horneff, G; Kempf, Christoph; Kaise, R; Korinthenberg, R; Körholz, D; Mauz-Körholz, C; Nadal, D; Niggemann, B; Roos, R; Späth, Peter; Wahn, V; Wehmeier, A; Zepp, F; Zielen, S (2007). Herstellung von intravenös verabreichbaren Immunglobulinen und Pathogensicherheit. In: Wahn, Volker (ed.) Klinischer Einsatz von Immunglobulinen (pp. 28-47). Bremen et al.: UNI-MED

Conference or Workshop Item

Quattrocchi, S.; Ruprecht, N.; Bonsch, C.; Bieli, S.; Zurcher, C.; Boller, K.; Kempf, C.; Ros, C. (2012). Early steps of human parvovirus B19 infection. In: USGEB Annual Meeting 2012.

Quattrocchi, S.; Ruprecht, N.; Bonsch, C.; Bieli, S.; Zurcher, C.; Boller, K.; Kempf, C.; Ros, C. (2012). Characterization of the Early Steps of Human Parvovirus B19 Infection. In: XIV International Parvovirus Workshop.

Käsermann, Fabian; Jürs, Mathias; Kempf, Christoph (2006). Prionen Erkrankungen beim Menschen und die Sicherheit von Blut und plasmatischen Produkten. In: Seifried, Erhard (ed.) Quo vadis Plasmaproteine (pp. 20-33). München: Gesellschaft für Thrombose- und Hämostaseforschung