PhD research (supervised by Simon Grabowsky):
My PhD research focuses on the synthesis and structural characterization of crystalline materials using high-resolution single-crystal X-ray diffraction, complemented by electron-density analysis and quantum-chemical calculations. A current focus is the study of polymorphism in Naproxen, a widely used nonsteroidal anti-inflammatory drug (NSAID) belonging to the class of arylpropionic acids, commonly prescribed for the treatment of pain, inflammation, and fever in conditions such as arthritis, musculoskeletal disorders, and acute injuries.
Master thesis (supervised by Julien Furrer)
My master thesis focused on optimizing the sensitivity of 2D NMR experiments, with particular emphasis on HSQC- and HMQC-based pulse sequences. After comparing conventional HSQC and HMQC experiments, I investigated sensitivity-enhanced variants (seHSQC and HMQCse), demonstrating important signal enhancement for CH₂, CH₃, and diastereotopic CHH′ groups under optimized delay conditions. The work further explored COSY-type extensions of these experiments, including multiplicity-edited and non-edited variants. In this context, a novel multiplicity-edited HMQC-COSY experiment was developed, providing strong signal intensities for both COSY and HMQC correlations. Fine-tuning of editing delays and incorporation of spin-echo elements enabled selective signal enhancement or suppression, offering improved control over spectral features and overall data quality.
Bachelor thesis (supervised by Jean-Louis Reymond):
My bachelor thesis focused on the synthesis of novel small-molecule inhibitors targeting Janus kinases (JAKs), key regulators of the immune response implicated in autoimmune diseases and cancer. I worked on four Triquinazine-based analogues with potential selectivity for JAK1, using different synthetic methods such as Strecker and amide coupling reactions. The compounds were successfully synthesized and characterized, and the results where published in 2026 as part of the Paper "Diversifying the triquinazine scaffold of a Janus kinase inhibitor" published in RSC Medicinal Chemistry.
