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  • 1984-1989 Studies of Veterinary Medicine. Complutense University, Madrid, Spain.
  • 1989-1991 Veterinary practitioner. Ayala Clinic, Madrid, Spain.
  • 1991-1992 Master student. National Veterinary Institute. University of Agricultural Sciences, Uppsala. Sweden. Thesis: Diagnosis and molecular characterization of mycoplasma F38.
  • 1993-1997 Ph.D. in Molecular Virology. University of Agricultural Sciences, Uppsala, Sweden. Thesis: “Diagnostic Application of the Polymerase Chain Reaction in Veterinary Microbiology”.
  • 1997-1999 Postdoc. National Veterinary Institute. University of Agricultural Sciences, Uppsala. Sweden.
  • 1998 Research fellow. Department of Medical Microbiology. University of South Florida, Tampa. USA.
  • 1999 Venia Docendi in infectious diseases at the University of Valencia. Faculty of Veterinary Medicine. Spain.
  • 1999-2001 Assistant Professor. Faculty of Veterinary Medicine. CEU. University of Valencia, Spain.
  • 2001-2016 Senior Scientist at CSL Behring, Bern. Switzerland.
  • 2013 Venia Docendi (Habilitation) in molecular virology at the University of Bern.
  • 2017- Group leader and lecturer. Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since 2021). University of Bern.

 

The main focus of our group is the study of the molecular mechanisms of host cell invasion by parvoviruses, which are among the smallest and simplest viruses known. They infect a wide range of animals and cause disease in humans. Because they depend on cellular functions for every step of their life cycle, parvoviruses are excellent models to study virus-host interactions. We are particularly interested in the early steps of the infection. As models, we use parvovirus minute virus of mice (MVM) and human parvovirus B19.

Our research also focuses on viruses representing a risk of transmission by blood-derived medicinal products, and in particular we aim at understanding the mechanisms underlying virus inactivation.

For a full list of publications, please see: 

https://ros.dcbp.unibe.ch/publications/

   

Publications embedded from BORIS (Bern Open Repository and Information System):

Number of items: 26.

Journal Article

Leisi, Remo; Wolfisberg, Raphael; Nowak, Thomas; Caliaro, Oliver; Hemmerle, Andreas; Roth, Nathan J.; Ros, Carlos (2021). Impact of the isoelectric point of model parvoviruses on viral retention in anion‐exchange chromatography. Biotechnology and bioengineering, 118(1), pp. 116-129. Wiley 10.1002/bit.27555

Ros, Carlos; Bieri, Jan; Leisi, Remo (2020). The VP1u of Human Parvovirus B19: A Multifunctional Capsid Protein with Biotechnological Applications. Viruses, 12(12), p. 1463. Molecular Diversity Preservation International MDPI 10.3390/v12121463

Leisi, Remo; Bieri, Jan; Roth, Nathan J.; Ros, Carlos (2020). Determination of parvovirus retention profiles in virus filter membranes using laser scanning microscopy. Journal of membrane science, 603, p. 118012. Elsevier 10.1016/j.memsci.2020.118012

Bieri, Jan; Ros, Carlos (2019). Globoside Is Dispensable for Parvovirus B19 Entry but Essential at a Postentry Step for Productive Infection. Journal of virology, 93(20) American Society for Microbiology 10.1128/JVI.00972-19

Bochud, Maëlle; Schäfer, Wolfram; Roth, Nathan J.; Ros, Carlos (2019). Characterization of a quasi-enveloped, fast replicating hepevirus from fish and its use as hepatitis E virus surrogate. Journal of virological methods, 263, pp. 111-119. Elsevier 10.1016/j.jviromet.2018.11.002

Caliaro, Oliver; Marti, Andrea; Ruprecht, Nico; Leisi, Remo; Subramanian, Suriyasri; Hafenstein, Susan; Ros, Carlos (2019). Parvovirus B19 Uncoating Occurs in the Cytoplasm without Capsid Disassembly and It Is Facilitated by Depletion of Capsid-Associated Divalent Cations. Viruses, 11(5), p. 430. Molecular Diversity Preservation International MDPI 10.3390/v11050430

Ros, Carlos; Bayat, Nooshin; Wolfisberg, Raphael; Almendral, José M (2017). Protoparvovirus Cell Entry. Viruses, 9(11) Molecular Diversity Preservation International MDPI 10.3390/v9110313

von Nordheim, Marcus; Boinay, Michel Thomas; Leisi, Remo; Kempf, Christoph; Ros, Carlos (2016). Cutthroat Trout Virus-Towards a Virus Model to Support Hepatitis E Research. Viruses, 8(10), p. 289. Molecular Diversity Preservation International MDPI 10.3390/v8100289

Leisi, Remo; von Nordheim, Marcus; Ros, Carlos; Kempf, Christoph (2016). The VP1u Receptor Restricts Parvovirus B19 Uptake to Permissive Erythroid Cells. Viruses, 8(10), p. 265. Molecular Diversity Preservation International MDPI 10.3390/v8100265

Wolfisberg, Raphael; Kempf, Christoph; Ros, Carlos (2016). Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus. Journal of virology, 90(11), pp. 5462-5474. American Society for Microbiology 10.1128/JVI.02967-15

Leisi, Remo; Di Tommaso, Chiarina; Kempf, Christoph; Ros, Carlos (2016). The Receptor-Binding Domain in the VP1u Region of Parvovirus B19. Viruses, 8(3), p. 61. Molecular Diversity Preservation International MDPI 10.3390/v8030061

Leisi, Remo; von Nordheim, Marcus; Kempf, Christoph; Ros, Carlos (2015). Specific Targeting of Proerythroblasts and Erythroleukemic Cells by the VP1u Region of Parvovirus B19. Bioconjugate chemistry, 26(9), pp. 1923-1930. American Chemical Society 10.1021/acs.bioconjchem.5b00321

Leisi, Remo; Ruprecht, Nico; Kempf, Christoph; Ros, Carlos (2013). Parvovirus B19 uptake is a highly selective process controlled by VP1u, a novel determinant of viral tropism. Journal of virology, 87(24), pp. 13161-13167. American Society for Microbiology 10.1128/JVI.02548-13

Wolfisberg, Raphael; Ruprecht, Nico; Kempf, Christoph; Ros, Carlos (2013). Impaired genome encapsidation restricts the in vitro propagation of human parvovirus B19. Journal of virological methods, 193(1), pp. 215-225. Elsevier 10.1016/j.jviromet.2013.06.003

Quattrocchi, Silva; Ruprecht, Nico; Bönsch, Claudia; Bieli, Sven; Zürcher, Christoph; Boller, Klaus; Kempf, Christoph; Ros, Carlos (2012). Characterization of the early steps of human parvovirus B19 infection. Journal of virology, 86(17), pp. 9274-9284. Baltimore: American Society for Microbiology 10.1128/JVI.01004-12

Bönsch, Claudia; Zuercher, Christoph; Lieby, Patricia; Kempf, Christoph; Ros, Carlos (2010). The globoside receptor triggers structural changes in the B19V capsid that facilitate virus internalization. Journal of virology, 84(22), pp. 11737-11746. Baltimore: American Society for Microbiology 10.1128/JVI.01143-10

Bönsch, Claudia; Kempf, Christoph; Müller, Ivo; Manning, Laurens; Laman, Moses; Davis, Timothy M.E.; Ros, Carlos (2010). Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication. PLoS neglected tropical diseases, 4(4), e669. San Francisco, Calif.: Public Library of Science 10.1371/journal.pntd.0000669

Boensch, Claudia; Kempf, Christoph; Ros, Carlos (2008). Interaction of parvovirus B19 with human erythrocytes alters virus structure and cell membrane integrity. Journal of virology, 82(23), pp. 11784-11791. Baltimore: American Society for Microbiology 10.1128/JVI.01399-08

Mani, Bernhard; Gerber, Marco; Lieby, Patricia; Boschetti, Nicola; Kempf, Christoph; Ros, Carlos (2007). Molecular mechanism underlying B19 virus inactivation and comparison to other parvoviruses. Transfusion, 47(10), pp. 1765-1774. Malden, Mass.: Wiley-Blackwell 10.1111/j.1537-2995.2007.01393.x

Ros, Carlos; Baltzer, Claudia; Mani, Bernhard; Kempf, Christoph (2006). Parvovirus uncoating in vitro reveals a mechanism of DNA release without capsid disassembly and striking differences in encapsidated DNA stability. Virology, 345(1), pp. 137-147. New York, N.Y.: Academic Press 10.1016/j.virol.2005.09.030

Mani, Bernhard; Baltzer, Claudia; Valle, Noelia; Almendral, José; Kempf, Christoph; Ros, Carlos (2006). Low pH-dependent endosomal processing of the incoming parvovirus minute virus of mice virion leads to externalization of the VP1 N-terminal sequence (N-VP1), N-VP2 cleavage, and uncoating of the full-length genome. Journal of virology, 80(2), pp. 1015-1024. Baltimore: American Society for Microbiology 10.1128/JVI.80.2.1015-1024.2006

Ros, Carlos; Gerber, Marco; Kempf, Christoph (2006). Conformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity. Journal of virology, 80(24), pp. 12017-12024. Baltimore: American Society for Microbiology 10.1128/JVI.01435-06

Ros, Carlos; Kempf, Christoph (2004). The ubiquitin-proteasome machinery is essential for nuclear translocation of incoming minute virus of mice. Virology, 324(2), pp. 350-360. Academic Press 10.1016/j.virol.2004.04.016

Ros, Carlos; Burckhardt, Christoph J; Kempf, Christoph (2002). Cytoplasmic trafficking of minute virus of mice: low-pH requirement, routing to late endosomes, and proteasome interaction. Journal of virology, 76(24), pp. 12634-12645. American Society for Microbiology 10.1128/JVI.76.24.12634-12645.2002

Ros, Carlos; Belák, Sándor (2002). Characterization of the glycoprotein B gene from ruminant alphaherpesviruses. Virus genes, 24(2), pp. 99-105. Nijhoff 10.1023/A:1014504730475

Conference or Workshop Item

Ros, Carlos (2017). Development of a relevant model virus system, cutthroat trout virus, for hepatitis E virus clearance studies (Unpublished). In: The principles of viral safety for biologicals and vaccines. Dubrovnik. 30 May-01 June 2017.

This list was generated on Sun Oct 24 16:39:04 2021 CEST.