Prof. Dr. Christian Leumann

Forschungsgruppenleiter / Rektor

Departement für Chemie, Biochemie und Pharmazie

Freiestrasse 3
CH - 3012 Bern


Professional Career:

  • 1977 - 1981  graduate studies in chemistry, Federal Institute of Technology (ETH) Zürich (Switzerland).
  • 1982 - 1986  Ph.D.-thesis "Biomimetic C-methylation reactions on corphin derivatives" at ETH (Prof. Albert Eschenmoser). A model study related to the sequence of the methylation steps in vitamin B12 biosynthesis.
  • 1987 - 1988  Post-doc at the Chemistry Department, University of California, Berkeley (Prof. Peter G. Schultz). Synthesis and characterization of catalytic antibodies.
  • 1988 - 1993  Oberassistent at the Laboratory of organic chemistry, ETH. Research work concerned with nucleic acid analogues.
  • 1993 -  Professor of bioorganic chemistry at the Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since 2021), University of Bern, (Switzerland).
  • 2001  Sabbatical stay (7 months) at the Scripps Research Institute in La Jolla (USA).
  • 2011  Sabbatical stay (3 months) at the Stanford University in Palo Alto (USA)


  • 1986  Silver medal of ETH for an outstanding Ph.D. thesis.
  • 1995  1995 Lectureship of the Society of Synthetic Organic Chemistry, Japan
  • 1997  Novartis Chemistry Lectureship 1997

Professional activities:

  • 1995 - 2002  Elected member of the board of directors of the Swiss Chemical Society (SCG).
  • 1999 - 2002  Elected president of the chemistry section of the Swiss Academy of Natural Sciences (SANW).
  • 2000 - 2009  Elected member of the research council (Forschungsrat) of the Swiss National Science Foundation (SNF).
  • 2003 - 2006  Chairman of the Department of Chemistry and Biochemistry
  • 2004 - 2006  Vice-president of Division II of the Swiss National Science Foundation.
  • 2007 - 2009  President of Division II of the Swiss National Science Foundation
  • 2010 -  Member of the editorial board of the journal Chimia and Artificial DNA: PNA & XNA
  • 2011 - 2016 Vice-Rector Research of the University of Bern
  • 2014  President of the consolidator grant panel (physical sciences and engineering) of the temporary backup schemes of the SNF
  • 2015  Rector elect, starting in August 2016
  • 2016 -  Rector of the University of Bern

Industrial activities:

  • 2012  Co-Founder of the biotech company Synthena AG, localized in Bern

Journal Article

Evéquoz, Damien; Verhaart, Ingrid E C; van de Vijver, Davy; Renner, Wolfgang; Aartsma-Rus, Annemieke; Leumann, Christian J (2021). 7′,5′-alpha-bicyclo-DNA: new chemistry for oligonucleotide exon splicing modulation therapy. Nucleic acids research, 49(21), pp. 12089-12105. Oxford University Press 10.1093/nar/gkab1097

Leumann, Christian J. (2021). Swiss Science: Quo Vadis after Exclusion from the European Framework Program? CHIMIA, 75(9), pp. 810-811. Schweizerische Chemische Gesellschaft 10.2533/chimia.2021.810

Röthlisberger, Pascal; Levi-Acobas, Fabienne; Leumann, Christian J.; Hollenstein, Marcel (2020). Enzymatic synthesis of biphenyl-DNA oligonucleotides. Bioorganic & medicinal chemistry, 28(11), p. 115487. Elsevier 10.1016/j.bmc.2020.115487

Levi-Acobas, Fabienne; Katolik, Adam; Röthlisberger, Pascal; Cokelaer, Thomas; Sarac, Ivo; Damha, Masad J.; Leumann, Christian J.; Hollenstein, Marcel (2019). Compatibility of 5-ethynyl-2’F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers. Organic & biomolecular chemistry, 17(35), pp. 8083-8087. Royal Society of Chemistry 10.1039/C9OB01515A

Istrate, Andrei; Johannsen, Silke; Istrate, Alena; Sigel, Roland K O; Leumann, Christian (2019). NMR solution structure of tricyclo-DNA containing duplexes: insight into enhanced thermal stability and nuclease resistance. Nucleic acids research, 47(9), pp. 4872-4882. Oxford University Press 10.1093/nar/gkz197

Frei, Sibylle; Katolik, Adam; Leumann, Christian (2019). Synthesis, biophysical properties, and RNase H activity of 6’-difluoro[4.3.0]bicyclo-DNA. Beilstein journal of organic chemistry, 15, pp. 79-88. Beilstein-Institut 10.3762/bjoc.15.9

Imbert, Marine; Blandel, Florence; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurelie (2019). Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease. Nucleic acid therapeutics, 29(5), pp. 256-265. Mary Ann Liebert 10.1089/nat.2018.0775

Willi, Jessica; Küpfer, Pascal; Evéquoz, Damien; Fernandez, Guillermo; Katz, Assaf; Leumann, Christian; Polacek, Norbert (2018). Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center. Nucleic acids research, 46(4), pp. 1945-1957. Information Retrieval Ltd. 10.1093/nar/gkx1308

Frei, Sibylle; Istrate, Andrei; Leumann, Christian (2018). 6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations. Beilstein journal of organic chemistry, 14, pp. 3088-3097. Beilstein-Institut 10.3762/bjoc.14.288

Istrate, Alena; Katolik, Adam; Istrate, Andrei; Leumann, Christian (2017). 2′β-Fluoro-Tricyclo Nucleic Acids (2′F-tc-ANA): Thermal Duplex Stability, Structural Studies, and RNase H Activation. Chemistry: a European journal, 23(43), pp. 10310-10318. Wiley 10.1002/chem.201701476

Diafa, Stella; Evéquoz, Damien; Leumann, Christian; Hollenstein, Marcel (2017). Enzymatic Synthesis of 7′,5′-Bicyclo-DNA Oligonucleotides. Chemistry - an Asian journal, 12(12), pp. 1347-1352. Asian Chemical Editorial Society 10.1002/asia.201700374

Evéquoz, Damien; Leumann, Christian (2017). Probing the Backbone Topology of DNA: Synthesis and Properties of 7′,5′-Bicyclo-DNA. Chemistry: a European journal, 23(33), pp. 7953-7968. Wiley 10.1002/chem.201700435

Robin, Valérie; Griffith, Graziella; Carter, John-Paul L.; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurélie (2017). Efficient SMN Rescue following Subcutaneous Tricyclo-DNA Antisense Oligonucleotide Treatment. Molecular Therapy - Nucleic Acids, 7, pp. 81-89. Nature Publishing Group 10.1016/j.omtn.2017.02.009

Röthlisberger, Pascal; Kaliginediand, Veerabhadrarao; Leumann, Christian (2017). Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates. Chemistry: a European journal, 23(9), pp. 2022-2025. Wiley 10.1002/chem.201605846

Relizani, Karima; Griffith, Graziella; Echevarría, Lucía; Zarrouki, Faouzi; Facchinetti, Patricia; Vaillend, Cyrille; Leumann, Christian; Garcia, Luis; Goyenvalle, Aurélie (2017). Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model. Molecular Therapy - Nucleic Acids, 8, pp. 144-157. Nature Publishing Group 10.1016/j.omtn.2017.06.013

Hari, Yvonne Ilona; Leumann, Christian; Schürch, Stefan (2017). What Hinders Electron Transfer Dissociation (ETD) of DNA Cations? Journal of the American Society for Mass Spectrometry, 28(12), pp. 2677-2685. Springer 10.1007/s13361-017-1791-z

Schuermann, David; Scheidegger, Simon P.; Weber, Alain R.; Bjørås, Magnar; Leumann, Christian J.; Schär, Primo (2016). 3CAPS – a structural AP-site analogue as a tool to investigate DNA base excision repair. Nucleic acids research, 44(5), pp. 2187-2198. Information Retrieval Ltd. 10.1093/nar/gkv1520

Röthlisberger, Pascal; Istrate, Alena; Marcaida Lopez, M. J.; Visini, Ricardo; Stocker, Achim; Reymond, Jean-Louis; Leumann, Christian (2016). X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. Chemical communications, 52(26), pp. 4749-4752. Royal Society of Chemistry 10.1039/c6cc00374e

Goyenvalle, Aurelie; Leumann, Christian; Garcia, Luis (2016). Therapeutic Potential of Tricyclo-DNA antisense oligonucleotides. Journal of neuromuscular diseases, 3(2), pp. 157-167. IOS Press 10.3233/jnd-160146

Medvecky, Michal; Istrate, Alena; Leumann, Christian (2015). Synthesis and Properties of 6′-Fluoro-tricyclo-DNA. The Journal of organic chemistry, 80(7), pp. 3556-3565. American Chemical Society 10.1021/acs.joc.5b00184

Goyenvalle, Aurelie; Griffith, Graziella; Babbs, Arran; Andaloussi, Samir El; Ezzat, Kariem; Avril, Aurelie; Dugovic, Branislav; Chaussenot, Remi; Ferry, Arnaud; Voit, Thomas; Amthor, Helge; Bühr, Claudia; Schürch, Stefan; Wood, Matthew J. A.; Davies, Kay E.; Vaillend, Cyrille; Leumann, Christian; Garcia, Luis (2015). Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers. Nature medicine, 21(3), pp. 270-275. Nature Publishing Group 10.1038/nm.3765

Istrate, Alena; Medvecky, Michal; Leumann, Christian J. (2015). 2′-Fluorination of Tricyclo-DNA Controls Furanose Conformation and Increases RNA Affinity. Organic letters, 17(8), pp. 1950-1953. American Chemical Society 10.1021/acs.orglett.5b00662

Calabretta, Alessandro; Küpfer, Pascal A.; Leumann, Christian J. (2015). The effect of RNA base lesions on mRNA translation. Nucleic acids research, 43(9), pp. 4713-4720. Information Retrieval Ltd. 10.1093/nar/gkv377

Ahmed, Kariem; Aoki, Yoshitsugu; Koo, Taeyoung; McClorey, Graham; Benner, Leif; Coenen-Stass, Anna; O'Donovan, Liz; Lehto, Taavi; Garciaguerra, Antonio; Nordin, Joel Zacharias; Saleh, Amer F.; Behlke, Mark A.; Morris, John; Goyenvalle, Aurelie; Dugovic, Branislav; Leumann, Christian Joerg; Gordon, Siamon; Gait, Michael J.; El-Andaloussi, Samir and Wood, Matthew J. A. (2015). Self-assembly into nanoparticles is essential for receptor mediated uptake of therapeutic antisense oligonucleotides. Nano letters, 15(7), pp. 4364-4374. American Chemical Society 10.1021/acs.nanolett.5b00490

Smith, Christine Catherine; Hollenstein, Marcel; Leumann, Christian (2014). The synthesis and application of a diazirine-modified uridine analogue for investigating RNA-protein interactions. RSC advances, 4(89), pp. 48228-48235. Royal Society of Chemistry 10.1039/c4ra08682a

Dugovic, Branislav; Wagner, Michael; Leumann, Christian J. (2014). Structure/affinity studies in the bicyclo-DNA series: Synthesis and properties of oligonucleotides containing bcen-T and iso-tricyclo-T nucleosides. Beilstein journal of organic chemistry, 10, pp. 1840-1847. Beilstein-Institut 10.3762/bjoc.10.194

Hollenstein, Marcel; Leumann, Christian (2014). Synthesis and Biochemical Characterization of Tricyclothymidine Triphosphate (tc-TTP). ChemBioChem, 15(13), pp. 1901-1904. Wiley-VCH 10.1002/cbic.201402116

Dugovic, Branislav; Leumann, Christian (2014). A 6'-Fluoro-Substituent in Bicyclo-DNA Increases Affinity to Complementary RNA Presumably by CF-HC Pseudohydrogen Bonds. The Journal of organic chemistry, 79(3), pp. 1271-1279. American Chemical Society 10.1021/jo402690j

Röthlisberger, Pascal; Wojciechowski, Filip; Leumann, Christian J. (2013). Enhancement of excess electron transfer efficiency in DNA containing a phenothiazine donor and multiple stable phenanthrenyl base pairs. Chemistry: a European journal, 19(35), pp. 11518-11521. Wiley 10.1002/chem.201301983

Gerber, Anna-Barbara; Leumann, Christian J. (2013). Synthesis and properties of isobicyclo-DNA. Chemistry - a European journal, 19(22), pp. 6990-7006. Wiley-VCH 10.1002/chem.201300487

Calabretta, Alessandro; Leumann, Christian J. (2013). Base pairing and miscoding properties of 1,N(6)-ethenoadenine- and 3,N(4)-ethenocytosine-containing RNA oligonucleotides. Biochemistry, 52(11), pp. 1990-1997. American Chemical Society 10.1021/bi400116y

Stoop, Matthias; Désiron, Camille; Leumann, Christian J. (2013). Nucleic acid sensing by an orthogonal reporter system based on homo-DNA. Artificial DNA: PNA & XNA, 4(1), pp. 28-33. Landes Bioscience 10.4161/adna.24227

Stucki, Silvan R.; Désiron, Camille; Nyakas, Adrien; Marti, Simon; Leumann, Christian J.; Schürch, Stefan (2013). Gas-phase Dissociation of homo-DNA Oligonucleotides. Journal of the American Society for Mass Spectrometry, 24(12), pp. 1997-2006. Springer-Verlag 10.1007/s13361-013-0729-3

Hollenstein, Marcel; Wojciechowski, Filip; Leumann, Christian J. (2012). Polymerase incorporation of pyrene-nucleoside triphosphates. Bioorganic and medicinal chemistry letters, 22(13), pp. 4428-4430. New York, N.Y.: Pergamon 10.1016/j.bmcl.2012.04.101

Wojciechowski, Filip; Lietard, Jory; Leumann, Christian J. (2012). 2-Pyrenyl-DNA: Synthesis, Pairing, and Fluorescence Properties. Organic letters, 14(20), pp. 5176-5179. Washington, D.C.: American Chemical Society 10.1021/ol302150a

Tanakaa, Mikiei; Jaruga, Pawel; Küpfer, Pascal A.; Leumann, Christian J.; Dizdaroglu, Miral; Sonntag, William E.; Chock, P. Boon (2012). RNA oxidation catalyzed by cytochrome c leads to its depurination and cross-linking, which may facilitate cytochrome c release from mitochondria. Free radical biology & medicine, 53(4), pp. 854-862. San Diego, Calif.: Elsevier 10.1016/j.freeradbiomed.2012.05.044

Haziri, Arben I.; Leumann, Christian J. (2012). Synthesis and Pairing Properties of Oligodeoxynucleotides Containing Bicyclo-RNA and Bicyclo-ANA Modifications. Journal of organic chemistry, 77(14), pp. 5861-5869. Washington, D.C.: American Chemical Society 10.1021/jo300554w

Murray, Sue; Ittig, Damian; Koller, Erich; Berdeja, Andres; Chappell, Alfred; Prakash, Thazha P.; Norrbom, Michaela; Swayze, Eric E.; Leumann, Christian J.; Seth, Punit P. (2012). TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues - a comparative study of oligonucleotide length, design and chemistry. Nucleic acids research, 40(13), pp. 6135-6143. London: Oxford University Press 10.1093/nar/gks273

Lietard, Jory; Leumann, Christian J. (2012). Synthesis, Pairing, and Cellular Uptake Properties of C(6′)-Functionalized Tricyclo-DNA. Journal of organic chemistry, 77(10), pp. 4566-4577. Washington, D.C.: American Chemical Society 10.1021/jo300648u

Yaren, Oezlem; Röthlisberger, Pascal; Leumann, Christian J. (2012). Synthesis and Incorporation into Oligodeoxynucleotides of Carbocyclic exo-Amino Nucleosides. Synthesis - journal of synthetic organic chemistry, 44(07), pp. 1011-1025. Stuttgart: Thieme 10.1055/s-0031-1289737

Tanaka, Mikiei; Han, Song; Küpfer, Pascal A.; Leumann, Christian J.; Sonntag, William E. (2011). Quantification of oxidized levels of specific RNA species using an aldehyde reactive probe. Analytical biochemistry, 417(1), pp. 142-148. San Diego, Calif.: Elsevier 10.1016/j.ab.2011.05.038

Tanaka, Mikiei; Song, Han; Küpfer, Pascal A.; Leumann, Christian J.; Sonntag, William E. (2011). An assay for RNA oxidation induced abasic sites using the Aldehyde Reactive Probe. Free radical research, 45(2), pp. 237-247. London: Informa Healthcare 10.3109/10715762.2010.535529

Ittig, Damian; Gerber, Anna-Barbara; Leumann, Christian J. (2011). Position-dependent effects on stability in tricyclo-DNA modified oligonucleotide duplexes. Nucleic acids research, 39(1), pp. 373-380. London: Oxford University Press 10.1093/nar/gkq733

Küpfer, Pascal A.; Leumann, Christian J. (2011). Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine. Nucleic acids research, 39(21), pp. 9422-9432. London: Oxford University Press 10.1093/nar/gkr673

Lietard, Jory; Ittig, Damian; Leumann, Christian J. (2011). Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues. Bioorganic & medicinal chemistry, 19(19), pp. 5869-5875. Amsterdam: Elsevier 10.1016/j.bmc.2011.08.022

Stoop, Matthias; Leumann, Christian J. (2011). Homo-DNA templated chemistry and its application to nucleic acid sensing. Chemical communications, 47(26), pp. 7494-7496. Cambridge: Royal Society of Chemistry 10.1039/C1CC11469G

Wojciechowski, Filip; Leumann, Christian J. (2011). Alternative DNA base-pairs: from efforts to expand the genetic code to potential material applications. Chemical Society reviews, 40(12), pp. 5669-5679. London: Royal Society of Chemistry 10.1039/C1CS15027H

Yaren, Oezlem; Mosimann, Markus; Leumann, Christian J. (2011). A Parallel Screen for the Discovery of Novel DNA Base Pairs. Angewandte Chemie (International ed.), 50(8), pp. 1935-1938. Weinheim: Wiley-VCH 10.1002/anie.201005300

Haziri, Arben I.; Silhar, Peter; Renneberg, Dorte; Leumann, Christian J. (2010). Synthesis of the Sugar Building Block of Bicyclo-RNA. Synthesis - journal of synthetic organic chemistry, 2010(05), pp. 823-827. Stuttgart: Thieme 10.1055/s-0029-1218650

Ittig, Damian; Luisier, Samuel; Weiler, Jan; Schümperli, Daniel; Leumann, Christian J. (2010). Improving gene silencing of siRNAs via tricyclo-DNA modification. Artificial DNA, PNA & XNA, 1(1), pp. 9-16. Austin, Tex.: Landes Bioscience 10.4161/adna.1.1.11385

Luisier, Samuel; Leumann, Christian J. (2010). Screening the Structural Space of Bicyclo-DNA: Synthesis and Properties of Bicyclo-DNA Functionalized at C(6’). Heterocycles, 82(1), pp. 775-790. Amsterdam: Elsevier Science 10.3987/com-10-s(e)65

Silhár, Peter; Leumann, Christian J. (2010). Parallel synthesis and nucleic acid binding properties of C(6')-[alpha]-functionalized bicyclo-DNA. Bioorganic & medicinal chemistry, 18(22), pp. 7786-7793. Amsterdam: Elsevier 10.1016/j.bmc.2010.09.064

Tanaka, Mikiei; Han, Song; Kupfer, Pascal A.; Leumann, Christian J.; Chock, Boon; Sonntag, William E. (2010). Identification of Selectively Damaged mRNA in Response to Oxidative Stress: Characterization of Abasic sites using an Aldehyde Reactive Probe. Free radical biology & medicine, 49(Supplement), S172. San Diego, Calif.: Elsevier 10.1016/j.freeradbiomed.2010.10.490

Kaufmann, Marco; Gisler, Michael; Leumann, Christian J. (2009). Stable cyclohexyl-phenyl recognition in the center of a DNA duplex. Angewandte Chemie (International ed.), 48(21), pp. 3810-3813. Weinheim: Wiley-VCH 10.1002/anie.200900153

Schnippering, Mathias; Zahn, Alain; Liu, Shi-Xia; Leumann, Christian; Decurtins, Silvio; Fermín, David J. (2009). Synthesis and electrochemical properties of TTF modified oligodeoxyribonucleotides. Chemical communications(37), p. 5552. Cambridge: Royal Society of Chemistry 10.1039/b907847a

Grigorenko, Nikolaj A.; Leumann, Christian J. (2009). 2-Phenanthrenyl-DNA: Synthesis, Pairing and Fluorescence Properties. Chemistry - a European journal, 15(3), pp. 639-645. Weinheim: Wiley-VCH 10.1002/chem.200801135

Stauffiger, Andrea; Leumann, Christian J. (2009). Screening the structural space of bicyclo-DNA: Synthesis and thermal melting properties of bc4,3-DNA. European journal of organic chemistry, 2009(8), pp. 1153-1162. Weinheim: Wiley-VCH 10.1002/ejoc.200801034

Luisier, Samuel; Leumann, Christian (2009). Synthesis and properties of bcox-DNA. Biopolymers, 92(4), pp. 312-313. Hoboken, N.J.: John Wiley & Sons, Inc.

Grigorenko, Nikolaj A.; Leumann, Christian J. (2008). Excess Electron Transport through a Stable Phenanthrenyl Pair in DNA. Chemical communications(42), p. 5417. Cambridge: Royal Society of Chemistry 10.1039/b810751c

Luisier, Samuel; Leumann, Christian J. (2008). Synthesis of bicyclo-DNA nucleosides with additional functionalization in the carbocyclic ring. CHIMIA, 62(4), pp. 270-272. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2008.270

Johar, Zeena; Zahn, Alain; Leumann, Christian J.; Jaun, Bernhard (2008). Solution structure of a DNA duplex containing a biphenyl base-pair. Chemistry - a European journal, 14(4), pp. 1080-1086. Weinheim: Wiley-VCH 10.1002/chem.200701304

Pallan, Pradeep S.; Ittig, Damian; Héroux, Annie; Wawrzak, Zdzislaw; Leumann, Christian J.; Egli, Martin (2008). Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles. Chemical communications(7), pp. 883-885. Cambridge: Royal Society of Chemistry 10.1039/b716390h

Luisier, Samuel; Leumann, Christian J. (2008). Screening the Structural and Functional Properties of Bicyclo-DNA: bcox-DNA. ChemBioChem, 9(14), pp. 2244-2253. Weinheim: Wiley-VCH 10.1002/cbic.200800322

Mayer, Alain; Leumann, Christian J. (2007). Pyrrolidino-DNA with bases corresponding to the 2-oxo deletion mutants of thymine and cytosine: synthesis and triplex forming properties. European journal of organic chemistry, 2007(24), pp. 4038-4049. Weinheim: Wiley-VCH 10.1002/ejoc.200700217

Ivanova, Gabriela; Reigadas, Sandrine; Ittig, Damian; Arzumanov, Andrey; Andreola, Marie-Line; Leumann, Christian; Toulmé, Jean-Jacques; Gait, Michael (2007). Tricyclo-DNA Containing Oligonucleotides as Steric Block Inhibitors of HIV-1 Tat-Dependent Trans Activation and HIV-1 Infectivity. Oligonucleotides, 17(1), pp. 54-65. Larchmont, N.Y.: Mary Ann Liebert 10.1089/oli.2006.0046

Stoop, Matthias; Zahn, Alain; Leumann, Christian J. (2007). A fluorescence quencher pair for DNA hybridization studies based on hydrophobic base surrogates. Tetrahedron, 63(17), pp. 3440-3449. Kidlington, UK: Elsevier Science 10.1016/j.tet.2006.12.095

Zahn, Alain; Leumann, Christian J. (2007). Biphenyl-DNA. CHIMIA, 61(4), pp. 159-160. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2007.159

Küpfer, Pascal A.; Crey-Desbiolles, Caroline; Leumann, Christian J. (2007). Trans-lesion synthesis and RNase H activity by reverse transcriptases on a true abasic RNA template. Nucleic acids research, 35(20), pp. 6846-6853. London: Information Retrieval Ltd. 10.1093/nar/gkm767

Stauffiger, Andrea; Leumann, Christian J. (2007). Synthesis of the bicyclo-[4.3.0]thymidyl nucleoside via Pd(II)-mediated ring expansion chemistry. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 615-619. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490407

Ivanova, Gabriela; Andrey, Arzumanov; Gait, Michael J.; Reigadas, Sandrine; Toulmé, Jean-Jacques; Andreola, Marie-Line; Ittig, Damian; Leumann, Christian (2007). Comparative Studies of Tricyclo-DNA- and LNA-Containing Oligonucleotides as Inhibitors of HIV-1 Gene Expression. Nucleosides, nucleotides & nucleic acids, 26(6-7), pp. 747-750. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701490928

Küpfer, Pascal A.; Leumann, Christian J. (2007). Photochemically induced RNA and DNA abasic sites. Nucleosides, nucleotides & nucleic acids, 26(8-9), pp. 1177-1180. Philadelphia, Pa.: Taylor & Francis 10.1080/15257770701527711

Leumann, Christian (2006). Sugar modification as a means to increase the biological performance of oligonucleotides. Nucleic Acids Symposium Series, 50(1), pp. 55-56. Oxford University Press 10.1093/nass/nrl167

Buchini, Sabrina; Leumann, Christian J. (2006). 2-O-Aminoethyl-oligoribonucleotides containing novel base analogues: synthesis and triple-helix formation at pyrimidine/purine inversion sites. European journal of organic chemistry, 2006(14), pp. 3152-3168. Weinheim: Wiley-VCH 10.1002/ejoc.200600182

Zahn, Alain; Leumann, Christian J. (2006). Synthesis of Functionalized Biphenyl-C-Nucleosides and their Incorporation into Oligodeoxynucleotides. Bioorganic & medicinal chemistry, 14(18), pp. 6174-6188. Amsterdam: Elsevier 10.1016/j.bmc.2006.05.072

Scheidegger, Simon P.; Leumann, Christian J. (2006). Synthesis and Pairing Properties of alpha-tricyclo-DNA. Chemistry - a European journal, 12(31), pp. 8014-8023. Weinheim: Wiley-VCH 10.1002/chem.200600597

Egli, Martin; Pallan, Pradeep S.; Pattanayek, Rekha; Wilds, Christopher J.; Lubini, Paolo; Minasov, George; Dobler, Max; Leumann, Christian J.; Eschenmoser, Albert (2006). Crystal structure of homo-DNA and Nature s choice of pentose over hexose in the genetic system. Journal of the American Chemical Society, 128(33), pp. 10847-10856. Washington, D.C.: American Chemical Society 10.1021/ja062548x

Küpfer, Pascal A.; Leumann, Christian J. (2006). The chemical stability of abasic RNA compared to abasic DNA. Nucleic acids research, 35(1), pp. 58-68. London: Oxford University Press 10.1093/nar/gkl948

Brotschi, Christine; Leumann, Christian J. (2005). RNA duplexes with biphenyl substituents as base replacements are less stable than DNA duplexes. Chemical communications(15), pp. 2023-2025. Royal Society of Chemistry 10.1039/B419278H

Brotschi, Christine; Mathis, Gérald; Leumann, Christian J. (2005). Bipyridyl- and biphenyl-DNA: A recognition motif based on interstrand aromatic stacking. Chemistry - a European journal, 11(6), pp. 1911-1923. Wiley-VCH 10.1002/chem.200400858

Crey-Desbiolles, Caroline; Ahn, Dae-Ro; Leumann, Christian J. (2005). Molecular beacons with a homo-DNA stem: improving target selectivity. Nucleic acids research, 33(8), e77. Oxford University Press 10.1093/nar/gni076

Hollenstein, Marcel; Leumann, Christian J. (2005). Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA. Journal of organic chemistry, 70(8), pp. 3205-3217. American Chemical Society 10.1021/jo047753e

Ittig, Damian; Renneberg, Dorte; Vonlanthen, David; Luisier, Samuel; Leumann, Christian J. (2005). Oligonucleotide analogues: From supramolecular principles to biological properties. Collection Symposium Series, 7, pp. 21-26. Prague: Academy of Sciences of the Czech Republic

Küpfer, Pascal A.; Leumann, Christian J. (2005). RNA abasic sites: preparation and trans-lesion synthesis by HIV-1 reverse transcriptase. ChemBioChem, 6(11), pp. 1970-1973. Wiley-VCH 10.1002/cbic.200500204

Leumann, Christian (2005). Genes under Restraint. Review of "Synthetic Nucleic Acids as Inhibitors of Gene Expression: Mechanisms, Applications and Therapeutic Implications", edited by Levon M. Khachigian, 200 p., CRC Press, 2004. ChemBioChem, 6(11), p. 2105. Wiley-VCH 10.1002/cbic.200500398

Leumann, Christian J. (2005). Tuning Molecular Recognition of RNA and DNA via Sugar Modification. CHIMIA, 59(11), pp. 776-779. Bern: Schweizerische Chemische Gesellschaft

Mayer, Alain; Häberli, Adrian; Leumann, Christian J. (2005). Synthesis and triplex forming properties of pyrrolidino pseudoisocytidine containing oligodeoxynucleotides. Organic & biomolecular chemistry, 3(9), pp. 1653-1658. Royal Society of Chemistry 10.1039/B502799C

Mosimann, Markus; Küpfer, Pascal A.; Leumann, Christian J. (2005). Synthesis and incorporation into DNA of a chemically stable, functional abasic site analogue. Organic letters, 7(23), pp. 5211-5214. American Chemical Society 10.1021/ol052045g

Zahn, Alain; Brotschi, Christine; Leumann, Christian J. (2005). Pentafluorophenyl phenyl interaction in biphenyl DNA. Chemistry - a European journal, 11(7), pp. 2125-2129. Wiley-VCH

Renneberg, Dorte; Leumann, Christian (2004). Exploring Hoogsteen and reversed-Hoogsteen duplex and triplex formation with tricyclo-DNA purine sequences. ChemBioChem, 5(8), pp. 1114-1118. Wiley-VCH 10.1002/cbic.200400069

Ittig, D.; Liu, Shi-Xia; Renneberg, Dorte; Schümperli, Daniel; Leumann, Christian (2004). Nuclear antisense effects in cyclophilin A pre-mRNA splicing by oligonucleotides: A comparison of tricyclo-DNA with LNA. Nucleic acids research, 32(1), pp. 346-353. Oxford University Press 10.1093/nar/gkh187

Buchini, S.; Leumann, Christian (2004). Stable and selective recognition of three base pairs in the parallel triple-helical DNA binding motif. Angewandte Chemie (International ed.), 43(30), pp. 3925-3928. Wiley-VCH 10.1002/anie.200460159

Dawson, Philip E.; Leumann, Christian (2004). Biopolymers: Challenge complex biological function with smart chemistry. Current opinion in chemical biology, 8(6), pp. 567-569. Elsevier 10.1016/j.cbpa.2004.10.006

Leumann, Christian (2003). Synthesis and Incorporation into PNA of Fluorinated Olefinic PNA (F-OPA) Monomers. Organic letters, 5(11), pp. 1987-1990. American Chemical Society

Vonlanthen, David; Leumann, Christian (2003). Hydroxycyclopentanone derivatives from D-Mannose via ring closing metathesis: An improved synthesis of a key intermediate of Tricyclo-DNA. Synthesis - journal of synthetic organic chemistry, 2003(07), pp. 1087-1090. Thieme 10.1055/s-2003-39177

Trafelet, Huldreich; Parel, Serge P; Leumann, Christian (2003). Oligodeoxynucleotide Duplexes Containing (5′S)-5′-C-Alkyl-Modified 2′-Deoxynucleosides: Can an Alkyl Zipper across the DNA Minor-Groove Enhance Duplex Stability? Helvetica chimica acta, 86(11), pp. 3671-3687. Verlag Helvetica Chimica Acta 10.1002/hlca.200390311

Mayer, Alain; Leumann, Christian (2003). A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry. Nucleosides, nucleotides & nucleic acids, 22(10), pp. 1919-1925. Taylor & Francis 10.1081/NCN-120025239

Hollenstein, Marcel; Gautschi, Daniel; Leumann, Christian (2003). Fluorinated peptide nucleic acid. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1191-1194. Taylor & Francis 10.1081/NCN-120022833

Hirtz, C.; Leumann, Christian (2003). Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1203-1206. Taylor & Francis 10.1081/NCN-120022836

Häberli, A.; Mayer, Alain; Leumann, Christian (2003). Pyrrolidino-DNA. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1187-1189. Taylor & Francis 10.1081/NCN-120022832

Gautschi, Daniel; Leumann, Christian (2003). Olefinic peptide nucleic acid (OPA). Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1211-1213. Taylor & Francis 10.1081/NCN-120022838

Buchini, S.; Leumann, Christian (2003). New nucleoside analogues for the recognition of pyrimidine-purine inversion sites. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1199-1201. Taylor & Francis 10.1081/NCN-120022835

Buchini, S.; Leumann, Christian (2003). Recent improvements in antigene technology. Current opinion in chemical biology, 7(6), pp. 717-726. Elsevier 10.1016/j.cbpa.2003.10.007

Buchini, S.; Leumann, Christian (2003). Dual recognition of a pyrimidine-purine inversion site: synthesis and binding properties of triplex forming oligonucleotides containing 2'-aminoethoxy-5-methyl-1 H -pyrimidin-2-one ribonucleosides. Tetrahedron letters, 44(27), pp. 5065-5068. Elsevier 10.1016/S0040-4039(03)01135-3

Brotschi, C.; Leumann, Christian (2003). Transition metal ligands as novel DNA-base substitutes. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1195-1197. Taylor & Francis 10.1081/NCN-120022834

Brotschi, C.; Leumann, Christian (2003). DNA with Hydrophobic Base Substitutes: A Stable, Zipperlike Recognition Motif Based On Interstrand-Stacking Interactions. Angewandte Chemie (International ed.), 42(14), pp. 1655-1658. Wiley-VCH 10.1002/anie.200250516

Becaud, J.; Pompizi, I.; Leumann, Christian (2003). Propagation of melting cooperativity along the phosphodiester backbone of DNA. Journal of the American Chemical Society, 125(50), pp. 15338-15342. American Chemical Society 10.1021/ja035313j

Ahn, D. R.; Mosimann, Markus; Leumann, Christian (2003). Synthesis of cyclopentane amide DNA (cpa-DNA) and its pairing properties. Journal of organic chemistry, 68(20), pp. 7693-7699. American Chemical Society 10.1021/jo034143q

Ahn, D. R.; Mosimann, Markus; Leumann, Christian (2003). Synthesis of a cyclopentane amide DNA analogue and its base pairing properties. Nucleosides, nucleotides & nucleic acids, 22(5-8), pp. 1207-1210. Taylor & Francis 10.1081/NCN-120022837

Schürch, Stefan; Bernal-Mendez, E.; Leumann, Christian (2002). Electrospray tandem mass spectrometry of mixed-sequence RNA/DNA oligonucleotides. Journal of the American Society for Mass Spectrometry, 13(8), pp. 936-945. Springer 10.1016/s1044-0305(02)00413-0

Renneberg, Dorte; Leumann, Christian (2002). Watson-Crick base-pairing properties of tricyclo-DNA. Journal of the American Chemical Society, 124(21), pp. 5993-6002. American Chemical Society 10.1021/ja025569+

Prévot, I.; Leumann, Christian (2002). Evaluation of novel third strand bases for the recognition of a C-G base-pair in the parallel DNA triple-helical binding motif. Helvetica chimica acta, 85(2), pp. 502-515. Verlag Helvetica Chimica Acta 10.1002/1522-2675(200202)85:2<502::AID-HLCA502>3.0.CO;2-L

Leumann, Christian (2002). DNA analogues:from supramolecular principles to biological properties. Bioorganic & medicinal chemistry, 10(4), pp. 841-854. Elsevier 10.1016/S0968-0896(01)00348-0

Keller, B. M.; Leumann, Christian (2002). Synthesis and incorporation into a-DNA of a novel conformationally constrained alpha-nucleoside analogue. Synthesis - journal of synthetic organic chemistry, 2002(06), pp. 789-796. Thieme 10.1055/s-2002-25755

Häberli, A.; Leumann, Christian (2002). DNA binding properties of oligodeoxynucleotides containing pyrrolidino C-nucleosides. Organic letters, 4(19), pp. 3275-3278. American Chemical Society 10.1021/ol026537u

Bernal-Méndez, E.; Leumann, Christian (2002). Stability and kinetics of nucleic acid triplexes with chimaeric DNA/RNA third strands. Biochemistry, 41(41), pp. 12343-12349. American Chemical Society 10.1021/bi025937m

Ahn, D. R.; Egger, A.; Lehmann, C.; Pitsch, S.; Leumann, Christian (2002). Bicyclo[3.2.1]amide-DNA: a chiral, non-chiroselective base-pairing system. Chemistry - a European journal, 8(23), pp. 5312-5322. Wiley-VCH 10.1002/1521-3765(20021202)8:23<5312::AID-CHEM5312>3.0.CO;2-M

Renneberg, Dorte; Bouliong, Emilie; Reber, Ulrich; Schümperli, Daniel; Leumann, Christian J. (2002). Antisense properties of tricyclo-DNA. Nucleic acids research, 30(13), pp. 2751-2757. Oxford University Press 10.1093/nar/gkf412

Trafelet, H. U.; Stulz, E.; Leumann, Christian (2001). Synthesis of (5' S )-5'- C -Alkyl-2'-deoxynucleosides. Helvetica chimica acta, 84(1), pp. 87-105. Verlag Helvetica Chimica Acta 10.1002/1522-2675(20010131)84:1<87::AID-HLCA87>3.0.CO;2-1

Parel, S. P.; Marfurt, J.; Leumann, Christian (2001). DNA triple-helix formation at pyrimidine-purine inversion sites. Nucleosides, nucleotides & nucleic acids, 20(4-7), pp. 411-417. Taylor & Francis 10.1081/NCN-100002315

Parel, S. P.; Leumann, Christian (2001). Triple-helix formation in the antiparallel binding motif of oligodeoxynucleotides containing N(9)- and N(7)-2-aminopurine deoxynucleosides. Nucleic acids research, 29(11), pp. 2260-2267. Information Retrieval Ltd. 10.1093/nar/29.11.2260

Leumann, Christian (2001). Conformationally Restricted Oligonucleotide Analogues 'Made in Bern': A Mini Review. CHIMIA, 55(12), pp. 1041-1044. Bern: Schweizerische Chemische Gesellschaft

Leumann, Christian (2001). Design and Evaluation of Oligonucleotide Analogues. CHIMIA, 55(4), pp. 295-301. Bern: Schweizerische Chemische Gesellschaft

Häberli, A.; Leumann, Christian (2001). Synthesis of pyrrolidine C-nucleosides via Heck reaction. Organic letters, 3(3), pp. 489-492. American Chemical Society 10.1021/ol007029s

Brotschi, C.; Häberli, A.; Leumann, Christian (2001). A Stable DNA Duplex Containing a Non-Hydrogen-Bonding and Non-Shape-Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor. Angewandte Chemie (International ed.), 40(16), pp. 3012-3014. Wiley-VCH 10.1002/1521-3773%2820010817%2940:16%3C3012::AID-ANIE3012%3E3.0.CO;2-Y

Bernal-Méndez, E.; Leumann, Christian (2001). Conformational diversity versus nucleic acid triplex stability, a combinatorial study. Journal of biological chemistry, 276(38), pp. 35320-35327. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M105794200

Stulz, E.; Bürgi, Hans-Beat; Leumann, Christian (2000). Zr(IV)-tetraphenylporphyrinates as nuclease mimicks: structural kinetic and mechanistic studies on phosphate diester transesterifications. Chemistry - a European journal, 6(3), pp. 523-536. Wiley-VCH 10.1002/(SICI)1521-3765(20000204)6:3<523::AID-CHEM523>3.0.CO;2-1

Schütz, Rolf; Cantin, Michel; Roberts, Christopher; Greiner, Beate; Uhlmann, Eugen; Leumann, Christian (2000). Olefinic Peptide Nucleic Acids (OPAs): New Aspects of the Molecular Recognition of DNA by PNA. Angewandte Chemie (International ed.), 39(7), pp. 1250-1253. Wiley-VCH 10.1002/(sici)1521-3773(20000403)39:7<1250::aid-anie1250>;2-e

Pompizi, I.; Häberli, A.; Leumann, Christian (2000). Oligodeoxynucleotides containing conformationally constrained abasic sites: a UV- and fluorescence spectroscopic investigation on duplex stability and structure. Nucleic acids research, 28(14), pp. 2702-2708. Information Retrieval Ltd. 10.1093/nar/28.14.2702

Parel, S. P.; Leumann, Christian (2000). Synthesis and pairing properties of oligodeoxynucleotides containing N7-(purine-2-amine deoxynucleosides). Helvetica chimica acta, 83(9), pp. 2514-2526. Verlag Helvetica Chimica Acta 10.1002/1522-2675(20000906)83:9<2514::AID-HLCA2514>3.0.CO;2-X

Keller, B. M.; Leumann, Christian (2000). Bicyclo-[3.2.1]-DNA: On the Structural and Energetic Role of the Furanose Subunit in Complementary Strand Recognition of DNA. Angewandte Chemie (International ed.), 39(13), pp. 2278-2281. Wiley-VCH

Stulz, E.; Leumann, Christian (1999). X-ray structure and solvolytic activity towards phosphate diesters of a zirconium(IV) complex. Journal of the Chemical Society, Chemical Communications(3), pp. 239-240. Royal Society of Chemistry 10.1039/a809101c

Steffens, R.; Leumann, Christian (1999). Synthesis and Thermodynamic and Biophysical Properties of Tricyclo-DNA. Journal of the American Chemical Society, 121(14), pp. 3249-3255. American Chemical Society 10.1021/ja983570w

Simon, H.; Förtsch, I.; Burckhardt, G.; Gabrielyan, A.; Birch-Hirschfeld, E.; Stelzner, A.; Prévot-Halter, I.; Leumann, Christian; Zimmer, C. (1999). Triple helix formation inhibits DNA gyrase activity. Antisense and Nucleic Acid Drug Development, 9(6), pp. 527-531. Mary Ann Liebert 10.1089/oli.1.1999.9.527

Roberts, C. D.; Schütz, R.; Leumann, Christian (1999). The synthesis of a thymine containing E-olefinic peptide nucleic acid (OPA) monomer. Synlett, 1999(6), pp. 819-821. Thieme 10.1055/s-1999-2711

Roberts, C. D.; Epple, C.; Leumann, Christian (1999). Bicyclo[3.2.1]-DNA: a DNA analog containing a rigid backbone and a flexible base-pairing region. Nucleosides & Nucleotides, 1999(18), pp. 1413-1415. Dekker 10.1080/07328319908044736

Prévot-Halter, I.; Leumann, Christian (1999). Selective Recognition of a C-G base-pair in the parallel DNA triple-helical binding motif. Bioorganic and medicinal chemistry letters, 9(18), pp. 2657-2660. Pergamon 10.1016/S0960-894X(99)00451-5

Meier, Roland; Grüschow, S.; Leumann, Christian (1999). Nucleic acid analogs with restricted conformational flexibility in the sugar-phosphate backbone (Bicyclo-DNA). Part 7. Synthesis and properties of oligodeoxynucleotides containing [(3'S,5'S,6'R)-6'-amino-2'-deoxy-3',5'-ethano-beta-D-ribofuranosyl]thymine (6'-amino-bicyclothymidine). Helvetica chimica acta, 82(11), pp. 1813-1828. Verlag Helvetica Chimica Acta 10.1002/(SICI)1522-2675(19991110)82:11<1813::AID-HLCA1813>3.0.CO;2-0

Egger, A.; Leumann, Christian (1999). Bicyclo[3.2.1]amide-DNA: Synthesis and base-pairing properties. Synlett, 1999(Sup. 1), pp. 913-916. Thieme 10.1055/s-1999-3113

Sauter, Guido; Stulz, Eugen; Leumann, Christian (1998). Distamycin-NA: A DNA Analog with an Aromatic Heterocyclic Polyamide Backbone. Part 1. Synthesis and structural analysis of monomers and dimers containing the nucleobase uracil. Helvetica chimica acta, 81(1), pp. 14-34. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810103

Sauter, Guido; Leumann, Christian (1998). Distamycin-NA: A DNA analog with an aromatic heterocyclic polyamide backbone. Part 2. Solid-phase synthesis of distamycin-NAs containing the nucleobase uracil: Unexpected solvent participation in the coupling step. Helvetica chimica acta, 81(5-8), pp. 916-931. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810512

Marfurt, Judith; Leumann, Christian (1998). Evidence for C−H⋅⋅⋅O Hydrogen Bond Assisted Recognition of a Pyrimidine Base in the Parallel DNA Triple-Helical Motif. Angewandte Chemie (International ed.), 37(1-2), pp. 175-177. Wiley-VCH 10.1002/(sici)1521-3773(19980202)37:1/2<175::aid-anie175>;2-p

Guo, M. J.; Hildbrand, S.; Leumann, Christian; McLaughlin, L. W.; Waring, M. J. (1998). Inhibition of DNA polymerase reaction by pyrimidine nucleotide analogues lacking the 2-keto group. Nucleic acids research, 26(8), pp. 1863-1869. Oxford University Press 10.1093/nar/26.8.1863

Groebke, Katrin; Hunziker, Jürg; Fraser, William; Peng, Ling; Diederichsen, Ulf; Zimmermann, Kaspar; Holzner, Armin; Leumann, Christian; Eschenmoser, Albert (1998). Warum Pentose- und nicht Hexose-Nucleinsäuren??. Teil V. (Purin-Purin)-Basenpaarung in der homo-DNS-Reihe: Guanin, Isoguanin, 2,6-Diaminopurin und Xanthin. Helvetica chimica acta, 81(3-4), pp. 375-474. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810302

Epple, C.; Leumann, Christian; Stoeckli-Evans, H. (1998). (1'S,5'S,6'R,8'S)-1-[6'-Acetoxy-8'-hydroxy-2'-oxabicyclo[3.2.1]oct-5'-yl)oxymethyl]-N4-ben zoylcytosine. Acta Crystallographica, Section C: Crystal Structure Communications, 54(8), pp. 1141-1143. International Union of Crystallography 10.1107/S010827019800184X

Epple, C.; Leumann, Christian (1998). Bicyclo[3.2.1]-DNA, a new DNA analog with a rigid backbone and flexibly linked bases: pairing properties with complementary DNA. Chemistry & biology, 5(4), pp. 209-216. Current Biology Ltd. 10.1016/S1074-5521(98)90634-2

Egger, A.; Hunziker, J.; Rihs, G.; Leumann, Christian (1998). Synthesis of bridgehead-functionalized bicyclo[3.2.1]octanes via intramolecular titanium- and tributylstannane-induced pinacol coupling. Helvetica chimica acta, 81(3-4), pp. 734-743. Verlag Helvetica Chimica Acta 10.1002/hlca.19980810323

Steffens, R.; Leumann, Christian (1997). Tricyclo-DNA: A phosphodiester-backbone based DNA analog exhibiting strong complementary base-pairing properties. Journal of the American Chemical Society, 119(47), pp. 11548-11549. American Chemical Society 10.1021/ja972597x

Steffens, R.; Leumann, Christian (1997). Nucleic-acid analogs with constraint conformational flexibility in the sugar-phosphate backbone "Tricyclo-DNA". Part 1. Preparation of [(5'R,6'R)-2-deoxy-3',5'-ethano-5',6'-methano-beta-D-ribofuranosyl]thymine and -adenine, and the corresponding phosphoramidites for oligonucleotide synthesis. Helvetica chimica acta, 80(8), pp. 2426-2439. Verlag Helvetica Chimica Acta 10.1002/hlca.19970800812

Marfurt, J.; Parel, S. P.; Leumann, Christian (1997). Strong, specific, monodentate G-C base-pair recognition by N7-inosine derivatives in the pyrimidine-purine-pyrimidine triple-helical binding motif. Nucleic acids research, 25(10), pp. 1875-1882. Oxford University Press 10.1093/nar/25.10.1875

Hildbrand, S.; Blaser, A.; Parel, S. P.; Leumann, Christian (1997). 5-Substituted 2-Aminopyridine C-nucleosides as protonated cytidine equivalents: Increasing efficiency and selectivity in DNA triple helix formation. Journal of the American Chemical Society, 119(24), pp. 5499-5511. American Chemical Society 10.1021/ja9704904

Cantin, M.; Schütz, R.; Leumann, Christian (1997). Synthesis of the monomeric building blocks of Z-olefinic PNA (Z-OPA) containing the bases adenine and thymine. Tetrahedron letters, 38(24), pp. 4211-4214. Elsevier 10.1016/S0040-4039(97)00871-X

Savithri, D.; Leumann, Christian; Scheffold, R. (1996). Synthesis of a building block for a nucleic acid analog with a chiral flexible peptide backbone. Helvetica chimica acta, 79(1), pp. 288-294. Verlag Helvetica Chimica Acta 10.1002/hlca.19960790128

Marfurt, J.; Stulz, E.; Trafelet, H. U.; Zingg, A.; Leumann, Christian; Hazenkamp, M.; Judd, R.; Schenker, S.; Strouse, G.; Ward, T. R.; Förtsch, M.; Hauser, Jürg; Bürgi, Hans-Beat (1996). 7-(2'-deoxy-alpha-D-ribofuranosyl)-hypoxanthine. Acta Crystallographica, Section C: Crystal Structure Communications, 52(3), pp. 713-716. Wiley-Blackwell 10.1107/S0108270195012662

Marfurt, J.; Hunziker, Jürg; Leumann, Christian (1996). Recognition of a G-C base pair by alpha-N7-deoxyinosine within the pyrimidine-purine-pyrimidine triple helical motif. Bioorganic and medicinal chemistry letters, 6(24), pp. 3021-3024. Pergamon 10.1016/S0960-894X(96)00561-6

Litten, J. C.; Leumann, Christian (1996). Nucleic-Acid analogs with restricted conformational flexibility in the sugar-phosphate backbone (Bicyclo-DNA), Part 6, Probing the influence of torsion angle gamma on DNA duplex stability: Synthesis and properties of oligodeoxynucleotides containing [(3'S,5'S)-2'-deoxy-3',5'-ethano- -D-ribofuranosyl]adenine and -thymine (5'epi-bicyclodeoxynucleosides). Helvetica chimica acta, 79(4), pp. 1129-1146. Verlag Helvetica Chimica Acta 10.1002/hlca.19960790421

Hildbrand, Stefan; Leumann, Christian; Scheffold, Rolf (1996). Synthesis of Carbocyclic C-Nucleosides Containing Nonnatural Pyrimidine Bases. Helvetica chimica acta, 79(3), pp. 702-709. Verlag Helvetica Chimica Acta 10.1002/hlca.19960790312

Hildbrand, Stefan; Leumann, Christian (1996). Enhancing DNA Triple Helix Stability at Neutral pH by the Use of Oligonucleotides Containing a More Basic Deoxycytidine Analog. Angewandte Chemie (International ed.), 35(17), pp. 1968-1970. Wiley-VCH 10.1002/anie.199619681

Bolli, M.; Trafelet, H. U.; Leumann, Christian (1996). Watson-Crick base-pairing properties of bicyclo-DNA. Nucleic acids research, 24(23), pp. 4660-4667. Oxford University Press 10.1093/nar/24.23.4660

Bolli, M.; Litten, C.; Schütz, R.; Leumann, Christian (1996). Bicyclo-DNA: a Hoogsteen-selective pairing system. Chemistry & biology, 3(3), pp. 197-206. Current Biology Ltd. 10.1016/S1074-5521(96)90263-X

Litten, J. C.; Epple, C.; Leumann, Christian (1995). Bicyclo-Oligonucleotides with Inverted Configuration at C(5'): Synthesis and Properties. Bioorganic and medicinal chemistry letters, 5(12), pp. 1231-1234. Pergamon 10.1016/0960-894X(95)00201-4

Bolli, Martin; Lubini, Paolo; Leumann, Christian (1995). Nucleic-Acid Analogs with Restricted Conformational Flexibility in the Sugar-Phosphate Backbone (‘Bicyclo-DNA’). Part 5. Synthesis, Characterization, and Pairing Properties of Oligo-αlpha-D-(bicyclodeoxynucleotides) of the Bases Adenine and Thymine (αlpha-Bicyclo-DNA). Helvetica chimica acta, 78(8), pp. 2077-2096. Verlag Helvetica Chimica Acta 10.1002/hlca.19950780816

Bolli, Martin; Leumann, Christian (1995). Triple-Helix Formation of Oligodeoxynucleotides Containing [(3′S,5′R)-2′-Deoxy-3′,5′-ethano-β-D-ribofuranosyl]nucleosides (“Bicyclo-deoxynucleosides”). Angewandte Chemie (International ed.), 34(6), pp. 694-696. Wiley-VCH 10.1002/anie.199506941

Tarköy, M.; Bolli, M.; Leumann, Christian (1994). Nucleic acid analogues with restricted conformational flexibility in the sugar phosphate backbone (bicyclo-DNA), Part 3, Synthesis, pairing properties and calorimetric determination of duplex and triplex stability of decanucleotides from (3'S,5'R)-2-Deoxy-3',5'-ethano-beta-D-ribofuranosyladenine and thymine. Helvetica chimica acta, 77(3), pp. 716-744. Verlag Helvetica Chimica Acta 10.1002/hlca.19940770315

Tarköy, Markus; Leumann, Christian (1993). Synthesis and Pairing Properties of Decanucleotides from (3′S,5′R)-2′-Deoxy-3′, 5′-ethano-β-D-ribofuranosyladenine and -thymine. Angewandte Chemie (International ed.), 32(10), pp. 1432-1434. Wiley-VCH 10.1002/anie.199314321

Tarköy, M.; Bolli, M.; Schweizer, B.; Leumann, Christian (1993). Nucleic Acid analogues with constraint conformational flexibility in the sugar phosphate backbone (bicyclo-DNA), Part I, Preparation of (3'S,5'R)-2'-Deoxy-3',5'-ethano-beta-D-ribofuranosyl-nucleosides (Bicyclonucleosides). Helvetica chimica acta, 76(1), pp. 481-510. Verlag Helvetica Chimica Acta 10.1002/hlca.19930760132

Otting, G.; Billeter, M.; Wüthrich, K.; Roth, H. J.; Leumann, Christian; Eschenmoser, A. (1993). Warum Pentose und nicht Hexose-Nucleinsäuren? TeilIV, Homo-DNS: 1H-,13C-,31P- und 15N NMR spektroskopische Untersuchungen von ddGlc (A-A-A-A-A-T-T-T-T-T) in wässriger Lösung. Helvetica chimica acta, 76(8), pp. 2701-2756. Verlag Helvetica Chimica Acta 10.1002/hlca.19930760802

Hunziker, Jürg; Roth, H. J.; Böhringer, M.; Giger, A.; Diederichsen, U.; Göbel, M.; Krishnan, R.; Jaun, B.; Leumann, Christian; Eschenmoser, A. (1993). Warum Pentose und nicht Hexose-Nucleinsäuren?, Teil III, Oligo,2',3'-dideoxy-beta-D-glucopyranosyl)-nucleotide (Homo-DNS): Paarungseigenschaften. Helvetica chimica acta, 76(1), pp. 259-352. Verlag Helvetica Chimica Acta 10.1002/hlca.19930760119

Egli, M.; Lubini, P.; Bolli, M.; Dobler, M.; Leumann, Christian (1993). Crystal structure of a parallel duplex of a deoxycytidyl-(3'-5')-deoxycytidine analogue containing intranucleosidyl C(3')-C(5') ethylene bridges. Journal of the American Chemical Society, 115(13), pp. 5855-5856. American Chemical Society 10.1021/ja00066a076

Neidlein, U.; Leumann, Christian (1992). Antiparallel thymine-thymine duplexes in oligonucleotides containing alfa- and beta-thymidine. Tetrahedron letters, 33(52), pp. 8057-8060. Elsevier 10.1016/S0040-4039(00)74716-2

Böhringer, M.; Roth, H. J.; Hunziker, J.; Göbel, M.; Krishnan, R.; Giger, A.; Schweizer, B.; Schreiber, J.; Leumann, Christian; Eschenmoser, A. (1992). Warum Pentose und nicht Hexose-Nucleinsäuren? Teil II, Oligonucleotide aus 2',3'-dideoxy-beta-D-glucopyranosylbausteinen ("Homo-DNS): Herstellung. Helvetica chimica acta, 75(5), pp. 1416-1477. Verlag Helvetica Chimica Acta 10.1002/hlca.19920750503

Venugopalan, Paloth; Venkatesan, K.; Klausen, Jörg; Novotny-Bregger, Elisabeth; Leumann, Christian; Eschenmoser, Albert; Dunitz, Jack D. (1991). On the Methyl-Transfer Reaction in Crystalline Methyl 2-(Methylthio)benzenesulfonate: a Thermally Induced Non-Topochemical Solid-State Reaction. Helvetica chimica acta, 74(3), pp. 662-669. Verlag Helvetica Chimica Acta 10.1002/hlca.19910740323

Groebke, Katrin; Leumann, Christian (1990). A Method for Preparing Oligodeoxynucleotides Containing an Apurinic Site. Helvetica chimica acta, 73(3), pp. 608-617. Verlag Helvetica Chimica Acta 10.1002/hlca.19900730309

Shokat, K. M.; Leumann, Christian; Sugasawara, R.; Schultz, P. G. (1989). A new strategy for the generation of catalytic antibodies. Nature, 338(6212), pp. 269-271. Macmillan Journals Ltd. 10.1038/338269a0

Shokat, Kevan M.; Leumann, Christian; Sugasawara, Renee; Schultz, Peter G. (1988). An Antibody-Mediated Redox Reaction. Angewandte Chemie (International ed.), 27(9), pp. 1172-1174. Wiley-VCH 10.1002/anie.198811721

Leumann, Christian; Früh, Thomas; Göbel, Michael; Eschenmoser, Albert (1987). Chemistry of Pyrrocorphins: Biomimetic Regioselectivity of C-Methylation at the Ligand Periphery of Magnesium(II) Uropyrrocorphinate(Type I)-octanitriles. Angewandte Chemie (International ed.), 26(3), pp. 261-264. Wiley-VCH 10.1002/anie.198702611

Leumann, Christian; Eschenmoser, Albert (1984). Chemistry of pyrrocorphins: methylative opening of the macrocycle between rings A and D, a side reaction in the peripheral C-methylation of a 20-methyl-pyrrocorphinate. Journal of the Chemical Society, Chemical Communications(9), p. 583. Royal Society of Chemistry 10.1039/c39840000583

Leumann, Christian; Hilpert, Kurt; Schreiber, Jakob; Eschenmoser, Albert (1983). Chemistry of pyrrocorphins: C-methylations at the periphery of pyrrocorphins and related corphinoid ligand systems. Journal of the Chemical Society, Chemical Communications(23), p. 1404. Royal Society of Chemistry 10.1039/c39830001404

Hilpert, Kurt; Leumann, Christian; Davis, Anthony P.; Eschenmoser, Albert (1983). Chemistry of pyrrocorphins: synthesis of isobacteriochlorins and pyrrocorphins bearing a methyl group at the meso position between rings A and D. Journal of the Chemical Society, Chemical Communications(23), p. 1401. Royal Society of Chemistry 10.1039/c39830001401

Book Section

Diafa, Stella; Evéquoz, Damien; Leumann, Christian; Hollenstein, Marcel (2019). Synthesis and Enzymatic Characterization of Sugar-Modified Nucleoside Triphosphate Analogs. In: Shank, Nathaniel (ed.) Non-Natural Nucleic Acids. Methods in Molecular Biology: Vol. 1973 (pp. 1-13). New York, NY: Springer New York 10.1007/978-1-4939-9216-4_1

Küpfer, Pascal A.; Leumann, Christian J. (2014). Oxidative Damage on RNA Nucleobases. In: Erdmann, Volker A.; Markiewicz, Wojciech T.; Barciszewski, Jan (eds.) Chemical Biology of Nucleic Acids. RNA Technologies (pp. 75-94). Heidelberg: Springer 10.1007/978-3-642-54452-1_5

Leumann, Christian (2012). Selbstreplizierende Moleküle und der Ursprung des Lebens: Evolution im Reagenzglas. In: Dubach, Martina (ed.) Evolution wohin? Die Folgen der darwinschen Theorie (pp. 71-84). Zürich: vdf Hochschulverlag

Hunziker, Jürg; Leumann, Christian (1995). Nucleic Acid Analogues: Synthesis and Properties. In: Ernst, Beat; Leumann, Christian (eds.) Modern Synthetic Methods 1995 (pp. 331-417). Basel: Verlag Helvetica Chimica Acta

Bolli, M.; Lubini, P.; Tarköy, M.; Leumann, Christian (1994). Synthesis characterization and pairing properties of an alpha-DNA-analogue with restricted conformational flexibility in the sugar-phosphate backbone: (alpha-bicyclo-DNA). In: Sanghvi, Yogesh S.; Cook, P. Dan (eds.) Carbohydrate modifications in antisense research. ACS Symposium Series: Vol. 580 (pp. 100-117). Washington: American Chemical Society 10.1021/bk-1994-0580.ch007

Conference or Workshop Item

Hari, Yvonne; Leumann, Christian; Schürch, Stefan (15 September 2016). Gas-phase properties of natural and modified nucleic acid duplexes. CHIMIA, 70(7/8). Schweizerische Chemische Gesellschaft

Koch, Miriam; Küpfer, Pascal; Leumann, Christian; Polacek, Norbert; Willi, Jessica (9 July 2016). Oxidized bases in the ribosome's peptidyl transferase center and their effects on translation (Unpublished). In: EMBO Conference Ribosome – Structure and Function 2016. Strasbourg, France. 06.-10.07.2016.

Hari, Yvonne; Schürch, Stefan; Leumann, Christian (4 September 2015). Elucidation of the gas-phase structure of a sugar-modified DNA analogue (Unpublished). In: SCS Fall Meeting. Lausanne. 04.09.2015.

Imbert, M.; Griffith, G.; Benchaouir, R.; Beley, C.; Dugovic, Branislav; Leumann, Christian; Garcia Popa-Lisseanu, Ana Maria; Goyenvalle, A. (2015). Therapeutic strategies for Huntington's. Human Gene Therapy, 26(10), A80-A81. Mary Ann Liebert

Goyenvalle, A.; Hofstetter, Robin Valentin; Garcia, L.; Dugovic, Branislav; Leumann, Christian (2014). Tricyclo-DNA for the treatment of neuromuscular diseases. Neuromuscular disorders, 24(Supplement 1), S3. Elsevier

Robin, Valerie; Ittig, Damian; Voit, Thomas; Leumann, Christian J.; Garcia, Luis (22 October 2012). SMN rescue by using oligonucleotides of tricyclo-DNA to induce exon 7 inclusion in SMN2 mRNA. Human gene therapy, 23(10), A37-A38. Mary Ann Liebert Inc.

Goyenvalle, A.; Babbs, A.; Avril, A.; Griffiths, G.; Dugovic, B.; Davies, K.E.; Leumann, Christian; Garcia, L. (October 2012). Tricyclo-DNA: A promising chemistry for the synthesis of antisense molecules for splice-switching approaches in DMD. Neuromuscular disorders, 22(9-10), p. 907. Elsevier 10.1016/j.nmd.2012.06.340

Leumann, Christian J. (2011). Shaping Nucleic Acids for Applications in Therapy: The Tricyclo-DNA Story - an Update. In: Hocek, M. (ed.) Chemistry of Nucleic Acid Components, Cesky-Krumlov, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic. Prague.

Ittig, Damian; Schümperli, Daniel; Leumann, Christian J. (2008). Tc-DNA modified siRNA. Nucleic Acids Symposium Series, 52(1), pp. 501-502. Oxford University Press 10.1093/nass/nrn254

Scheidegger, Simon P.; Leumann, Christian J. (2008). Strand invasion properties and serum stability of a-tricyclo-DNA. Nucleic Acids Symposium Series, 52(1), pp. 139-140. Oxford University Press 10.1093/nass/nrn071

Stauffiger, Andrea; Leumann, Christian J. (2008). Synthesis and structural analysis of [4.3.0]-bicyclothymidine. Nucleic Acids Symposium Series, 52(1), pp. 267-268. Oxford University Press 10.1093/nass/nrn135

Luisier, Samuel; Silhar, Peter; Leumann, Christian J. (2008). Highly beta-selective, N-iodosuccinimide-mediated nucleosidation to bicyclo- and tricyclo-nucleosides. Nucleic Acids Symposium Series, 52(1), pp. 581-582. Oxford University Press 10.1093/nass/nrn294