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Lebenslauf

  • 1979 – 1986: Studies in Biochemistry, University of Zürich.
    Diploma thesis on “Differential Chemical Modification of Cytochrome-c” in the lab of Prof. H.R. Bosshard​
  • 1986 – 1992: Awarded PhD Thesis in Chemistry at the University of Zürich:
    “Identification and Isolation of the Tocopherol-Cyclase of Anabaena-Variabilis Kützing” (supervisor Prof. W.-D. Woggon)
  • 1993 – 1996: Postdoctoral research at the Society for Biotechnological Research (GBF) Braunschweig, Germany.
    “Synthesis and crystallization of semi-synthetic D-amino acid oxidase for X-ray crystallography and biosensor applications”
  • 1996 – 2000: Postdoctoral research fellow at the Institute for Biochemistry and Molecular Biology, University of Bern.
    “In-vitro expression and characterization of human Tocopherol-binding proteins”
  • 2001 – 2003: Postdoctoral research fellow at the Department of Chemistry and Biochemistry, University of Bern.
    “Structure determination of human lipid-transfer proteins”
  • 2003 – 2006: Research group leader in the group of Prof. Peter Dimroth at the Institute of Microbiology, ETHZ.
    “Functional and structural investigations on the ATP-synthase of bacillus sp. TA2”
  • Since 2006: Lecturer and group leader at the Department of Chemistry and Biochemistry / Department of Chemistry, Biochemistry and Pharmaceutical Sciences (since 2021), University of Bern.
    “Structural and functional studies on lipid carriers associated with retinopathies and neurological disorders”
  • Since 2014: Associate professor in biochemistry at the University of Bern (Assoziierter Professor)

 

Forschungsschwerpunkt

Current Research Interests

Our goal is to understand the linkage between dysfunctional SEC14-like proteins and human diseases. In particular, we try to understand how members of the SEC14-like family of proteins recognize and shuttle specific lipids between compartments. Besides the biophysical aspects of targeted lipid-transfer we aim to understand how human retinopathies and neurological disorders are associated with missense mutations of the carriers.

Major research projects

  • Vitamin E retention and homeostasis
  • The role of Vitamin A binding proteins in the chemistry of vision
  • Modulation of cholesterol endosynthesis by SEC14-like proteins

Publikationen

Liste der im neuen BORIS Portal erfassten Publikationen

(Anpassung der Publikationen im BORIS Portal: https://boris-portal.unibe.ch)

Publication Year Type

Mitgliedschaften

  • Berner Chemische Gesellschaft (BCG)
  • Biochemische Vereinigung Bern (BVB)